Advanced Materials

Drug Delivery: Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery (Adv. Mater. 27/2012)

Authors

  • Ran Mo,

    1. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China
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  • Qiong Sun,

    1. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China
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  • Jingwei Xue,

    1. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China
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  • Nan Li,

    1. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China
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  • Wenyuan Li,

    1. Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia
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  • Can Zhang,

    Corresponding author
    1. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China
    • Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
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  • Qineng Ping

    1. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China
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Abstract

Liposomes with multistage pH-response to a mildly acidic tumor extracellular matrix and acidic intracellular compartments are like rockets for transporting anticancer drugs to mitochondria, as reported by C. Zhang and co-workers. On page 3659, liposomes reverse the charge of the tumor microenvironment, enhancing cellular uptake (white flying rocket), escape from endolysosomes (blue sphere), and delivery to mitochondria in tumor cells (black flying rocket), providing a safe, efficient carrier platform for cascade drug delivery on the basis of a kinetic process.

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