Lipid Nanoparticles: Peptide Targeted Lipid Nanoparticles for Anticancer Drug Delivery (Adv. Mater. 28/2012)

Authors

  • Timothy R. Pearce,

    1. Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, 55455, USA
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  • Kamlesh Shroff,

    1. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, 55455, USA
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  • Efrosini Kokkoli

    Corresponding author
    1. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, 55455, USA
    • Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, 55455, USA.
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Abstract

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Nanoparticles reach the tumor through the “leaky” tumor vasculature that allows the transfer of large molecules out of the blood stream. Once in the tumor microenvironment targeting peptides on the surface of the nanoparticles allow specific binding by tumor-cell receptors and subsequent cell internalization. On page 3803, E. Kokkoli and co-workers review the recent strategies used to create peptide-targeted lipid nano-particles to improve cancer therapy.

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