• ferritin;
  • nanoprobes;
  • hydrogels;
  • bioassay platforms;
  • biomedical applications
Thumbnail image of graphical abstract

On page 4739, J. Lee and co-workers report a novel bioassay platform that is based on ferritinbased nanoprobe (FBNP) hydrogel, a threedimensional gel matrix with high porosity, large surface area, and high water content. The FBNP hydrogel entraps a large number of stable FBNPs with precise loading control and the antigen probes on FBNPs are homogeneously oriented as well as uniformly spaced within the gel matrix. Finally, the FBNP hydrogel is successfully used for a multiplex diagnosis of AIDS and SS with high sensitivity, specificity, and reproducibility.