Biomedical Applications: A Novel Bioassay Platform Using Ferritin-Based Nanoprobe Hydrogel (Adv. Mater. 35/2012)

Authors

  • Eun Jung Lee,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
    Search for more papers by this author
  • Keum-Young Ahn,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
    Search for more papers by this author
  • Jong-Hwan Lee,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
    Search for more papers by this author
  • Jin-Seung Park,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
    Search for more papers by this author
  • Jong-Am Song,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
    Search for more papers by this author
  • Sang Jun Sim,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
    Search for more papers by this author
  • Eun Bong Lee,

    1. College of Medicine, Seoul National University, Daehak-Ro 103, Seoul 110-744, Republic of Korea
    Search for more papers by this author
  • Young Joo Cha,

    1. College of Medicine, Chung-ang University, Heuksuk-Ro 84, Seoul 156-756, Republic of Korea
    Search for more papers by this author
  • Jeewon Lee

    Corresponding author
    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
    • Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea.
    Search for more papers by this author

Abstract

original image

On page 4739, J. Lee and co-workers report a novel bioassay platform that is based on ferritinbased nanoprobe (FBNP) hydrogel, a threedimensional gel matrix with high porosity, large surface area, and high water content. The FBNP hydrogel entraps a large number of stable FBNPs with precise loading control and the antigen probes on FBNPs are homogeneously oriented as well as uniformly spaced within the gel matrix. Finally, the FBNP hydrogel is successfully used for a multiplex diagnosis of AIDS and SS with high sensitivity, specificity, and reproducibility.

Ancillary