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Tissue Engineering: The Design of a Heterocellular 3D Architecture and its Application to Monitoring the Behavior of Cancer Cells in Response to the Spatial Distribution of Endothelial Cells (Adv. Mater. 39/2012)

Authors

  • Wonjae Lee,

    Corresponding author
    1. Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 USA Stanford, CA, USA
    2. Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA
    • Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 USA Stanford, CA, USA.

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  • Jon Park

    Corresponding author
    1. Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 USA Stanford, CA, USA
    2. Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA
    • Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 USA Stanford, CA, USA.

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Abstract

original image

Spatial cell distribution is one of the critical features for governing cellular interactions and subsequent cell behaviors. On page 5339, Jon Park and Wonjae Lee suggest a novel method to build a 3D hierarchical cellular structure by stacking cell-attached micro plate structures with specific configurations within hydrogel layers. As a model system, the 3D architecture of a liver lobule, a structural unit of the liver, was reconstructed (red: hepatocytes in a hydrogel layer, green: endothelial cells on a micro plate structure) in which the desired heterocellular interactions were successfully restored.

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