Spatial cell distribution is one of the critical features for governing cellular interactions and subsequent cell behaviors. On page 5339, Jon Park and Wonjae Lee suggest a novel method to build a 3D hierarchical cellular structure by stacking cell-attached micro plate structures with specific configurations within hydrogel layers. As a model system, the 3D architecture of a liver lobule, a structural unit of the liver, was reconstructed (red: hepatocytes in a hydrogel layer, green: endothelial cells on a micro plate structure) in which the desired heterocellular interactions were successfully restored.
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