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Keywords:

  • cell patterning;
  • biological complexity;
  • tissue engineering;
  • microstructures;
  • thermoresponsive platforms;
  • multicellular organization;
  • cancer biology;
  • developmental biology;
  • drug discovery
Thumbnail image of graphical abstract

Dynamic microwells are fabricated to control spatial organization of multiple cell types in defined geometries. These microwells exhibit temperature-dependent shape-changing characteristics at different temperatures, which are exploited to pattern multiple cell types at different temperatures. Different cell types are spatially distributed in circular and square microwells. The technique presented by Ali Khademhosseini, Robert Langer, and co-workers on page 5543 could be useful to recapitulate various native tissue microenvironments for applications in tissue engineering, cancer biology, developmental biology, and drug discovery.