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Keywords:

  • cell mechanics;
  • cell shapes;
  • confocal microscopy;
  • micropatterning;
  • cortical actin
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A tomography approach is used to reconstruct 3D cell shapes and the shapes/positions of the nuclei within these cells simultaneously. Bartosz A. Grzybowski, Kristiana Kandere-Grzybowska and co-workers show on page 5719 that cells subjected to well-defined microconfinements of various diameters allow for relating the steady-state shapes of cells to their staticmechanical properties. The observed shapes show striking regularities between different cell types and all fit to a model that takes into account the cell membrane, cortical actin, and the nucleus.