Label-Free Polypeptide-Based Enzyme Detection Using a Graphene-Nanoparticle Hybrid Sensor (Adv. Mater. 45/2012)



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A novel approach for the detection of enzymes using a graphene–nanoparticle (NP) hybrid biosensor is developed by Ki-Bum Lee and co-workers on page 6081. This biosensor can detect the activity of an enzyme and determine its concentration by measuring the change in electrical hysteresis that results from the dynamic interaction of the target enzyme with its corresponding peptide linker resulting in the release of nanoparticles.