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Advanced Materials

Recombinant Supercharged Polypeptides Restore and Improve Biolubrication

Authors

  • Deepak H. Veeregowda,

    1. University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, W.J. Kolff Institute, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
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  • Anke Kolbe,

    1. Department of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
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  • Henny C. van der Mei,

    1. University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, W.J. Kolff Institute, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
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  • Henk J. Busscher,

    1. University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, W.J. Kolff Institute, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
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  • Andreas Herrmann,

    1. Department of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
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  • Prashant K. Sharma

    Corresponding author
    1. University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, W.J. Kolff Institute, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    • University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, W.J. Kolff Institute, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
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Abstract

Recombinant supercharged polypeptides (SUPs) with low cytotoxicity are developed and applied to rejuvenate the lubrication of naturally occurring salivary conditioning films (SCFs). SUPs with 72 positive charges adsorbed and rigidified the SCFs and recruited mucins to form a hydrated layer. These SCFs with SUPs have higher mechanical strength and sustain lubricating effect for longer duration compared with only SCFs.

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