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Advanced Materials

Synthesis of Protein-Based, Rod-Shaped Particles from Spherical Templates using Layer-by-Layer Assembly

Authors

  • Zhimin Zhou,

    1. Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    2. Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, PR China
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  • Aaron C. Anselmo,

    1. Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
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  • Samir Mitragotri

    Corresponding author
    1. Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    • Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
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Abstract

Nanorods provide distinct advantages over their spherical counterparts for targeted drug delivery. Here, a novel method is described for the synthesis of biocompatible protein nanorods from spherical polystyrene templates using the layer-by-layer (LBL) technique. These nanorods can be used as a vehicle for the delivery of therapeutic agents to diseased sites.

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