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Diamond-Lipid Hybrids Enhance Chemotherapeutic Tolerance and Mediate Tumor Regression

Authors

  • Laura Moore,

    1. Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, 60208, USA
    Current affiliation:
    1. L. K. M. and E. K. C. contributed equally to this work.
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  • Edward Kai-Hua Chow,

    1. George Williams Hooper Foundation, University of California San Francisco, San Francisco, California, 94143, USA
    2. Cancer Science Institute of Singapore, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599
    Current affiliation:
    1. L. K. M. and E. K. C. contributed equally to this work.
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  • Eiji Osawa,

    1. NanoCarbon Research Institute, Shinshu University, Ueda, Nagano, Japan
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  • J. Michael Bishop,

    1. Department of Microbiology and Immunology, George Williams Hooper Foundation, University of California San Francisco, San Francisco, California, 94143, USA
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  • Dean Ho

    Corresponding author
    1. Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, 60208, USA
    2. Department of Mechanical Engineering, Northwestern University, Evanston, Illinois, 60208, USA
    3. Institute for Bionanotechnology in Medicine (IBNAM), Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago. Illinois, 60611, USA
    4. Division of Oral Biology and Medicine, Division of Advanced Prosthodontics, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, UCLA Department of Bioengineering, Jonsson Comprehensive Cancer Center, California NanoSystems Institute, Los Angeles, California, 90095, USA
    • Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, 60208, USA.
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Abstract

original image

Self-assembled nanodiamond-lipid hybrid particles (NDLPs) harness the potent interaction between the nanodiamond (ND)-surface and small molecules, while providing a mechanism for cell-targeted imaging and therapy of triple negative breast cancers. Epidermal growth factor receptor-targeted NDLPs are highly biocompatible particles that provide cell-specific imaging, promote tumor retention of ND-complexes, prevent epirubicin toxicities and mediate regression of triple negative breast cancers.

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