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Advanced Materials

Rapidly–Dissolvable Microneedle Patches Via a Highly Scalable and Reproducible Soft Lithography Approach

Authors

  • Katherine A. Moga,

    1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC
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    • K. A. M. and L. R. B. contributed equally to this work.

  • Lissett R. Bickford,

    1. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
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    • K. A. M. and L. R. B. contributed equally to this work.

  • Robert D. Geil,

    1. Institute for Advanced Materials, NanoScience and Technology, University of North Carolina at Chapel Hill, Chapel Hill, NC
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  • Stuart S. Dunn,

    1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC
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  • Ashish A. Pandya,

    1. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
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  • Yapei Wang,

    1. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
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  • John H. Fain,

    1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC
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  • Christine F. Archuleta,

    1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC
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  • Adrian T. O'Neill,

    1. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
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  • Joseph M. DeSimone

    Corresponding author
    1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC
    2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
    3. Institute for Advanced Materials, NanoScience and Technology, University of North Carolina at Chapel Hill, Chapel Hill, NC
    4. Department of Pharmacology, Eshelman School of Pharmacy, Carolina Center for Nanotechnology Excellence, Institute for Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
    5. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC
    6. Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York
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Abstract

Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.

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