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Advanced Materials

Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells

Authors

  • Akhilesh K. Gaharwar,

    1. Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard medical School, Cambridge, MA 02115, USA
    2. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Silvia M. Mihaila,

    1. Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard medical School, Cambridge, MA 02115, USA
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. 3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Dept. of Polymer Engineering, University of Minho, AvePark, Taipas, Guimarães 4806-909, Portugal
    4. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães 4806-909, Portugal
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Archana Swami,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
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  • Alpesh Patel,

    1. Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard medical School, Cambridge, MA 02115, USA
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Shilpa Sant,

    1. Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard medical School, Cambridge, MA 02115, USA
    2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
    3. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Rui L. Reis,

    1. 3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Dept. of Polymer Engineering, University of Minho, AvePark, Taipas, Guimarães 4806-909, Portugal
    2. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães 4806-909, Portugal
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  • Alexandra P. Marques,

    1. 3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Dept. of Polymer Engineering, University of Minho, AvePark, Taipas, Guimarães 4806-909, Portugal
    2. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães 4806-909, Portugal
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  • Manuela E. Gomes,

    Corresponding author
    1. 3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Dept. of Polymer Engineering, University of Minho, AvePark, Taipas, Guimarães 4806-909, Portugal
    2. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães 4806-909, Portugal
    • 3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Dept. of Polymer Engineering, University of Minho, AvePark, Taipas, Guimarães 4806-909, Portugal.
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  • Ali Khademhosseini

    Corresponding author
    1. Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard medical School, Cambridge, MA 02115, USA
    2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
    3. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    • Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard medical School, Cambridge, MA 02115, USA
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Abstract

Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.

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