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Advanced Materials

Defined Polymer–Peptide Conjugates to Form Cell-Instructive starPEG–Heparin Matrices In Situ

Authors

  • Mikhail V. Tsurkan,

    1. Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany, Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307 Dresden, Germany
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Karolina Chwalek,

    1. Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany, Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307 Dresden, Germany
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Silvana Prokoph,

    1. Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany, Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307 Dresden, Germany
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  • Andrea Zieris,

    1. Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany, Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307 Dresden, Germany
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  • Kandice R. Levental,

    Corresponding author
    1. Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany, Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307 Dresden, Germany
    Current affiliation:
    1. Department of Integrative Biology and Pharmacology, University, of Texas, Health Science Center at Houston, 6431, Fannin Street, Houston TX 77030
    • Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany, Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307 Dresden, Germany.===

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  • Uwe Freudenberg,

    Corresponding author
    1. Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany, Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307 Dresden, Germany
    • Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany, Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307 Dresden, Germany.===

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  • Carsten Werner

    1. Leibniz Institute of Polymer Research Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany, Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307 Dresden, Germany
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Abstract

Poly(ethylene glycol)-peptide- and glycosaminoglycan-peptide conjugates obtained by a regio-selective amino acid protection strategy are converted into cell-instructive hydrogel matrices capable of inducing morphogenesis in embedded human vascular endothelial cells and dorsal root ganglia.

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