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In Situ Self-Folding Assembly of a Multi-Walled Hydrogel Tube for Uniaxial Sustained Molecular Release

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Abstract

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This study presents a multi-walled poly(ethylene glycol) diacrylate hydrogel tube formed by the simple self-folding of a bi-layered hydrogel patch. The gel tube has the capability to release encapsulated molecules through designated pathways in a sustained manner. Therefore, the gel tube encapsulating the vascular endothelial growth factor significantly increases the vascular densities and vessel diameters at an implantation site.

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