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Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles

Authors

  • Jiwei Cui,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
    Current affiliation:
    1. J. Cui and R. De Rose contributed equally to this work.
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  • Robert De Rose,

    1. Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Current affiliation:
    1. J. Cui and R. De Rose contributed equally to this work.
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  • James P. Best,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Angus P. R. Johnston,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Sheilajen Alcantara,

    1. Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Kang Liang,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Georgina K. Such,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Stephen J. Kent,

    Corresponding author
    1. Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
    • Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia.
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  • Frank Caruso

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
    • Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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Abstract

original image

DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.

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