Advanced Materials

Microencapsulation of Chemotherapeutics into Monodisperse and Tunable Biodegradable Polymers via Electrified Liquid Jets: Control of Size, Shape, and Drug Release

Authors

  • Pouria Fattahi,

    1. Departments of Bioengineering and Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    Search for more papers by this author
  • Ali Borhan,

    1. Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    Search for more papers by this author
  • Mohammad Reza Abidian

    Corresponding author
    1. Departments of Bioengineering, Materials Science & Engineering and Chemical Engineering, Materials Research Institute, Pennsylvania State University, University Park, PA 16802, USA
    • Departments of Bioengineering, Materials Science & Engineering and Chemical Engineering, Materials Research Institute, Pennsylvania State University, University Park, PA 16802, USA.===

    Search for more papers by this author

Abstract

This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods.

original image

Ancillary