SEARCH

SEARCH BY CITATION

Keywords:

  • octacalcium phosphate;
  • bisphosphonate;
  • in vitro co-cultures
Thumbnail image of graphical abstract

Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP.