Crystalline Calcium Alendronate Obtained by Octacalcium Phosphate Digestion: A New Chance for Local Treatment of Bone Loss Diseases?
Article first published online: 9 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 25, Issue 33, pages 4605–4611, September 6, 2013
How to Cite
Boanini, E., Torricelli, P., Gazzano, M., Fini, M. and Bigi, A. (2013), Crystalline Calcium Alendronate Obtained by Octacalcium Phosphate Digestion: A New Chance for Local Treatment of Bone Loss Diseases?. Adv. Mater., 25: 4605–4611. doi: 10.1002/adma.201301129
- Issue published online: 3 SEP 2013
- Article first published online: 9 JUL 2013
- Manuscript Revised: 8 MAY 2013
- Manuscript Received: 12 MAR 2013
- octacalcium phosphate;
- in vitro co-cultures
Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP.