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Assembly of Free-Standing Polypeptide Films via the Synergistic Combination of Hyperbranched Macroinitiators, the Grafting-From Approach, and Cross-Chain Termination



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Cross-linked polypeptide-based films are fabricated via a novel and robust method employing surface-initiated ring opening polymerization of α-amino acid N-carboxyanhydrides (NCA-ROP). The judicious combination of amine-based hyperbranched macroinitiators and benzyl ester-protected NCA derivatives promotes network formation by cross-chain terminations, which allows the formation of stable cross-linked peptide-based capsules in a one-pot system.