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Keywords:

  • DNA hydrogel;
  • envelop and release;
  • permeable;
  • responsiveness;
  • single cell
Thumbnail image of graphical abstract

We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication.