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Advanced Materials

Fluorescent Nanoparticle Delivered dsRNA Toward Genetic Control of Insect Pests

Authors

  • Bicheng He,

    1. Department of Entomology, China Agricultural University, 100193 Beijing, China
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  • Yuan Chu,

    1. Department of Entomology, China Agricultural University, 100193 Beijing, China
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  • Meizhen Yin,

    Corresponding author
    1. State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology, 100029 Beijing, China
    • Meizhen Yin, State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology, 100029 Beijing, China.===

      Chunju An, Department of Entomology, China Agricultural University, 100193 Beijing, China===

      Jie Shen, Department of Entomology, China Agricultural University, 100193 Beijing, China===

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  • Klaus Müllen,

    1. Max Planck Institute for Polymer Research, 55128 Mainz, Germany
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  • Chunju An,

    Corresponding author
    1. Department of Entomology, China Agricultural University, 100193 Beijing, China
    • Meizhen Yin, State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology, 100029 Beijing, China.===

      Chunju An, Department of Entomology, China Agricultural University, 100193 Beijing, China===

      Jie Shen, Department of Entomology, China Agricultural University, 100193 Beijing, China===

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  • Jie Shen

    Corresponding author
    1. Department of Entomology, China Agricultural University, 100193 Beijing, China
    • Meizhen Yin, State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology, 100029 Beijing, China.===

      Chunju An, Department of Entomology, China Agricultural University, 100193 Beijing, China===

      Jie Shen, Department of Entomology, China Agricultural University, 100193 Beijing, China===

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Abstract

A fluorescent cationic core-shell nanoparticle efficiently enters into cells with high transfection efficacy. A FNP/CHT10-dsRNA complex is orally fed to insect pests and knocks down a midgut-specific chitinase gene of the Asian corn borer, which leads to death. This is the first report on the genetic control of insect pests through a non-viral gene delivery system to knock down key developmental gene expression.

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