Advanced Materials

Nanomaterials for Reducing Amyloid Cytotoxicity

Authors

  • Min Zhang,

    1. National Center for Nanoscience and Technology, Beijing 100190, China, Tel: 86-10-82545559, Fax: 86-10-62656765, Tel: 86-10-82545561, Fax: 86-10-62656765
    2. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, P.R. China
    Search for more papers by this author
  • Xiaobo Mao,

    1. National Center for Nanoscience and Technology, Beijing 100190, China, Tel: 86-10-82545559, Fax: 86-10-62656765, Tel: 86-10-82545561, Fax: 86-10-62656765
    Search for more papers by this author
  • Yue Yu,

    1. National Center for Nanoscience and Technology, Beijing 100190, China, Tel: 86-10-82545559, Fax: 86-10-62656765, Tel: 86-10-82545561, Fax: 86-10-62656765
    Search for more papers by this author
  • Chen-Xuan Wang,

    1. National Center for Nanoscience and Technology, Beijing 100190, China, Tel: 86-10-82545559, Fax: 86-10-62656765, Tel: 86-10-82545561, Fax: 86-10-62656765
    2. Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China
    Search for more papers by this author
  • Yan-Lian Yang,

    Corresponding author
    1. National Center for Nanoscience and Technology, Beijing 100190, China, Tel: 86-10-82545559, Fax: 86-10-62656765, Tel: 86-10-82545561, Fax: 86-10-62656765
    • National Center for Nanoscience and Technology, Beijing 100190, China, Tel: 86-10-82545559, Fax: 86-10-62656765, Tel: 86-10-82545561, Fax: 86-10-62656765.
    Search for more papers by this author
  • Chen Wang

    Corresponding author
    1. National Center for Nanoscience and Technology, Beijing 100190, China, Tel: 86-10-82545559, Fax: 86-10-62656765, Tel: 86-10-82545561, Fax: 86-10-62656765
    • National Center for Nanoscience and Technology, Beijing 100190, China, Tel: 86-10-82545559, Fax: 86-10-62656765, Tel: 86-10-82545561, Fax: 86-10-62656765.
    Search for more papers by this author

Abstract

This review is intended to reflect the recent progress on therapeutic applications of nanomaterials in amyloid diseases. The progress on anti-amyloid functions of various nanomaterials including inorganic nanoparticles, polymeric nanoparticles, carbon nanomaterials and biomolecular aggregates, is reviewed and discussed. The main functionalization strategies for general nanoparticle modifications are reviewed for potential applications of targeted therapeutics. The interaction mechanisms between amyloid peptides and nanomaterials are discussed from the perspectives of dominant interactions and kinetics. The encapsulation of anti-amyloid drugs, targeted drug delivery, controlled drug release and drug delivery crossing blood brain barrier by application of nanomaterials would also improve the therapeutics of amyloid diseases.

Ancillary