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Advanced Materials

Tuning of Cell–Biomaterial Anchorage for Tissue Regeneration

Authors

  • Aldo Leal-Egaña,

    Corresponding author
    1. Institute of Biomaterials, Friedrich-Alexander Universität Erlangen Nürnberg, Cauerstraße 6, 91058 Erlangen, Germany
    2. Laboratory of the Physics of the Cytoskeleton and Morphogenesis, LPCV/iRTSV/DSV/CEA, Batiment 40-20, 17 Rue Martyrs, 38054 Grenoble, France
    • Institute of Biomaterials, Friedrich-Alexander Universität Erlangen Nürnberg, Cauerstraße 6, 91058 Erlangen, Germany.
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  • Aránzazu Díaz-Cuenca,

    1. Instituto de Ciencia de Materiales de Sevilla (ICMS), Centro Mixto CSIC-Universidad de Sevilla, Avda. Américo Vespucio 49, Isla de la Cartuja, 41092 Seville, Spain
    2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Campus Río Ebro - Edificio I+D, Bloque 5, 1ª planta, c/Poeta Mariano, Esquillor s/n, Zaragoza, Aragon 50018, Spain
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  • Aldo R. Boccaccini

    1. Institute of Biomaterials, Friedrich-Alexander Universität Erlangen Nürnberg, Cauerstraße 6, 91058 Erlangen, Germany
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Abstract

Which mechanisms mediate cell attachment to biomaterials? What role does the surface charge or wettability play on cell–material anchorage? What are the currently investigated strategies to modify cell–matrix adherence spatiotemporally? Considering the development of scaffolds made of biocompatible materials to temporarily replace the structure and/or function of the extracellular matrix, focus is given to the analysis of the specific (i.e., cell adhesive peptide sequences) and unspecific (i.e., surface charge, wettability) mechanisms mediating cell-matrix interactions. Furthermore, because natural tissue regeneration is characterized by the dynamic attachment/detachment of different cell populations, the design of advanced scaffolds for tissue engineering, based in the spatiotemporal tuning of cell–matrix anchorage is discussed.

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