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Advanced Materials

Dielectrophoretically Aligned Carbon Nanotubes to Control Electrical and Mechanical Properties of Hydrogels to Fabricate Contractile Muscle Myofibers

Authors

  • Javier Ramón-Azcón,

    1. WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Samad Ahadian,

    1. WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Mehdi Estili,

    1. Materials Processing Unit, National Institute for Materials Science (NIMS), Tsukuba 305-0047, Japan
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  • Xiaobin Liang,

    1. WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan
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  • Serge Ostrovidov,

    1. WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan
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  • Hirokazu Kaji,

    1. Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan
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  • Hitoshi Shiku,

    1. Graduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan
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  • Murugan Ramalingam,

    1. WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan
    2. Centre for Stem Cell Research, A unit of the Institute for Stem Cell Biology and Regenerative Medicine, Christian Medical College Campus, Vellore 632002, India, Institut National de la Santé Et de la Recherche Médicale U977, Faculté de Chirurgie Dentaire, Université de Strasbourg, Strasbourg 67085, France
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  • Ken Nakajima,

    1. WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan
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  • Yoshio Sakka,

    1. Materials Processing Unit, National Institute for Materials Science (NIMS), Tsukuba 305-0047, Japan
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  • Ali Khademhosseini,

    Corresponding author
    1. Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA and Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea
    2. WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan
    • Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA and Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea
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  • Tomokazu Matsue

    Corresponding author
    1. Graduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan
    2. WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan
    • Graduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan.
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Abstract

Dielectrophoresis is used to align carbon nanotubes (CNTs) within gelatin methacrylate (GelMA) hydrogels in a facile and rapid manner. Aligned GelMA-CNT hydrogels show higher electrical properties compared with pristine and randomly distributed CNTs in GelMA hydrogels. The muscle cells cultured on these materials demonstrate higher maturation compared with cells cultured on pristine and randomly distributed CNTs in GelMA hydrogels.

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