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Dual Surface-Functionalized Janus Nanocomposites of Polystyrene/Fe3O4@SiO2 for Simultaneous Tumor Cell Targeting and Stimulus-Induced Drug Release

Authors

  • Feng Wang,

    1. Materials Science and Engineering Program, University of Cincinnati, Cincinnati, OH 45221, USA
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  • Giovanni M. Pauletti,

    1. James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
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  • Juntao Wang,

    1. Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, China
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  • Jiaming Zhang,

    1. Departments of Earth & Environmental Sciences, Nuclear Engineering & Radiological Sciences and Materials Science & Engineering, University of Michigan, Ann Arbor, MI 48109-1005, USA
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  • Rodney C. Ewing,

    1. Departments of Earth & Environmental Sciences, Nuclear Engineering & Radiological Sciences and Materials Science & Engineering, University of Michigan, Ann Arbor, MI 48109-1005, USA
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  • Yilong Wang,

    Corresponding author
    1. Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, China
    • Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, China.
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  • Donglu Shi

    Corresponding author
    1. Materials Science and Engineering Program, University of Cincinnati, Cincinnati, OH 45221, USA
    2. Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, China
    • Materials Science and Engineering Program, University of Cincinnati, Cincinnati, OH 45221, USA
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Abstract

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Folic acid (FA) and doxorubicin (DOX) are coupled separately onto Fe3O4@SiO2 and polystyrene surfaces of a unique polystyrene/Fe3O4@SiO2 Janus structure. This super-paramagnetic, dual-functionalized Janus nanocomposite enables effective tumor cell targeting and internalization via the folate receptor, and induces significant cancer cell death by controlled, stimulus-induced drug release under acidic conditions in endosomal compartments.

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