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Large-Scale Graphene Micropattern Nano-biohybrids: High-Performance Transducers for FET-Type Flexible Fluidic HIV Immunoassays

Authors

  • Oh Seok Kwon,

    1. World Class University program of Chemical, Convergence for Energy & Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Republic of Korea
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Seung Hwan Lee,

    1. School of Chemical and Biological Engineering, Bio-MAX Institute, Seoul National University, Seoul 151-744, Republic of Korea
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Seon Joo Park,

    1. World Class University program of Chemical, Convergence for Energy & Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Republic of Korea
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  • Ji Hyun An,

    1. World Class University program of Chemical, Convergence for Energy & Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Republic of Korea
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  • Hyun Seok Song,

    1. School of Chemical and Biological Engineering, Bio-MAX Institute, Seoul National University, Seoul 151-744, Republic of Korea
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  • Taejoon Kim,

    1. Alan G. MacDiarmid Energy Research Institute, Department of Polymer and Fiber System Engineering, Chonnam National University, Gwangju 500-757, South Korea
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  • Joon Hak Oh,

    1. School of Nano-Bioscience and Chemical Engineering, KIER-UNIST Advanced Center for Energy, Low Dimensional Carbon Materials Center, Ulsan National Institute of Science and Technology, Ulsan 689-798, Republic of Korea
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  • Joonwon Bae,

    1. Department of Applied Chemistry Dongduk Women's University, Seongbuk-gu, Seoul 136–714, Republic of Korea
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  • Hyeonseok Yoon,

    1. Alan G. MacDiarmid Energy Research Institute, Department of Polymer and Fiber System Engineering, Chonnam National University, Gwangju 500-757, South Korea
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  • Tai Hyun Park,

    Corresponding author
    1. School of Chemical and Biological Engineering, Bio-MAX Institute, Seoul National University, Seoul 151-744, Republic of Korea
    • School of Chemical and Biological Engineering, Bio-MAX Institute, Seoul National University, Seoul 151-744, Republic of Korea.
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  • Jyongsik Jang

    Corresponding author
    1. World Class University program of Chemical, Convergence for Energy & Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Republic of Korea
    • World Class University program of Chemical, Convergence for Energy & Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Republic of Korea
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Abstract

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Large-scale FET-type graphene micropatten (GM) nano-biohybrid-based immunosensor (GMNS) is fabricated in a controlled fashion to detect human immunodeficiency virus 2 antibody. Flexible GMNS shows a highly sensitive response and excellent mechanical bendability. The flexible GMNS in fluidic systems also has a stable response. This is the first experimental demonstration of a large-scale flexible fluidic FET-type immunoassay based on GM nano-biohybrids.

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