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Microbubbles from Gas-Generating Perfluorohexane Nanoemulsions for Targeted Temperature-Sensitive Ultrasonography and Synergistic HIFU Ablation of Tumors

Authors

  • Yang Zhou,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
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  • Zhigang Wang,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
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  • Yu Chen,

    1. State Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
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  • Hongxia Shen,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
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  • Zhenchun Luo,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
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  • Ao Li,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
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  • Qi Wang,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
    2. College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, P. R. China.
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  • Haitao Ran,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
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  • Pan Li,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
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  • Weixiang Song,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
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  • Zhu Yang,

    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
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  • Hangrong Chen,

    1. State Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
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  • Zhibiao Wang,

    1. College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, P. R. China.
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  • Guangmin Lu,

    1. Department of Radiology, General Hospital of Nanjing Military Base, Nanjing, 210002, P. R. China.
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  • Yuanyi Zheng

    Corresponding author
    1. Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China
    • Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing, Medical University, Chongqing, 400010, P. R. China.
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Abstract

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A special “small to big” temperature-responsive phase-transformation strategy based on the “acoustic droplet vaporization (ADV)” mechanism is developed for efficient targeted ultrasonography and synergistic high intensity focused ultrasound (HIFU) cancer surgery by engineering targeted nanoemulsions, which is systematically evaluated and successfully demonstrated in vitro, ex vivo, and in vivo.

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