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Keywords:

  • biomedical imaging;
  • cisplatin;
  • drug delivery;
  • self-assembly;
  • upconversion fluorescent
Thumbnail image of graphical abstract

By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.