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Advanced Materials

Scalable Manufacture of Built-to-Order Nanomedicine: Spray-Assisted Layer-by-Layer Functionalization of PRINT Nanoparticles

Authors

  • Stephen W. Morton,

    1. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Kevin P. Herlihy,

    1. Department of Chemistry, University of North Carolina at Chapel Hill, 257 Caudill Labs, South Road, Chapel Hill, North Carolina 27514, USA
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  • Kevin E. Shopsowitz,

    1. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Zhou J. Deng,

    1. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Kevin S. Chu,

    1. Department of Chemistry, University of North Carolina at Chapel Hill, 257 Caudill Labs, South Road, Chapel Hill, North Carolina 27514, USA
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  • Charles J. Bowerman,

    1. Department of Chemistry, University of North Carolina at Chapel Hill, 257 Caudill Labs, South Road, Chapel Hill, North Carolina 27514, USA
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  • Joseph M. DeSimone,

    Corresponding author
    1. Department of Chemistry, University of North Carolina at Chapel Hill, 257 Caudill Labs, South Road, Chapel Hill, North Carolina 27514, USA
    2. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA
    • Department of Chemistry, University of North Carolina at Chapel Hill, 257 Caudill Labs, South Road, Chapel Hill, North Carolina 27514, USA.
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  • Paula T. Hammond

    Corresponding author
    1. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    • Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • The authors wish to dedicate this paper to the memory of Officer Sean Collier, for his caring service to the MIT community and for his sacrifice.

Abstract

Scalable methods, PRINT particle fabrication, and spray-assisted Layer-by-Layer deposition are combined to generate uniform and functional nanotechnologies with precise control over composition, size, shape, and surface functionality. A modular and tunable approach towards design of built-to-order nanoparticle systems, spray coating on PRINT particles is demonstrated to achieve technologies capable of targeted interactions with cancer cells for applications in drug delivery.

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