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A Selective Artificial Enzyme Inhibitor Based on Nanoparticle-Enzyme Interactions and Molecular Imprinting

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Abstract

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A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and shows great target-selectivity over other enzymes of similar function and proteins of compaable mole cular weight.

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