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Controlled Cell Adhesion on Poly(dopamine) Interfaces Photopatterned with Non-Fouling Brushes

Authors

  • Cesar Rodriguez-Emmenegger,

    1. Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
    2. Zell- und Neurobiologie, Zoologisches Institut, Karlsruhe Institute of Technology (KIT), Haid-und-Neu-Str. 9, Karlsruhe and Institut für Funktionelle Grenzflächen (IFG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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    • [+]These authors contributed equally to this work

  • Corinna M. Preuss,

    1. Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
    2. Institut für Biologische Grenzflächen (IBG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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    • [+]These authors contributed equally to this work

  • Basit Yameen,

    1. Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
    2. Institut für Biologische Grenzflächen (IBG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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  • Ognen Pop-Georgievski,

    1. Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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  • Michael Bachmann,

    1. Zell- und Neurobiologie, Zoologisches Institut, Karlsruhe Institute of Technology (KIT), Haid-und-Neu-Str. 9, Karlsruhe and Institut für Funktionelle Grenzflächen (IFG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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  • Jan O. Mueller,

    1. Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
    2. Institut für Biologische Grenzflächen (IBG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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  • Michael Bruns,

    1. Institute for Applied Materials (IAM) and Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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  • Anja S. Goldmann,

    1. Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
    2. Institut für Biologische Grenzflächen (IBG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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  • Martin Bastmeyer,

    1. Zell- und Neurobiologie, Zoologisches Institut, Karlsruhe Institute of Technology (KIT), Haid-und-Neu-Str. 9, Karlsruhe and Institut für Funktionelle Grenzflächen (IFG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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  • Christopher Barner-Kowollik

    Corresponding author
    1. Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
    2. Institut für Biologische Grenzflächen (IBG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany
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Abstract

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Bioinspired poly(dopamine) (PDA) films are merged with antifouling poly(MeOEGMA) brushes utilizing a nitrile imine-mediated tetrazole-ene cycloaddition (NITEC)-based phototriggered surface encoding protocol. The antifouling brushes were photopatterned on PDA surfaces, leading cells to form confluent layers in the non-irradiated sections, while no adhesion occurred on the brushes resulting in a remarkably precise cell pattern. The presented strategy paves the way for the design of tailor-made patterned cell interfaces.

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