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Fabrication of Cysteine-Responsive Biomimetic Single Nanochannels by a Thiol-yne Reaction Strategy and Their Application for Sensing in Urine Samples

Authors

  • Zhongyue Sun,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P. R. China
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  • Cuiping Han,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P. R. China
    2. School of Medical Imaging, Xuzhou Medical College, Xuzhou, Jiangsu, P. R. China
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  • Miaomiao Song,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P. R. China
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  • Long Wen,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P. R. China
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  • Demei Tian,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P. R. China
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  • Haibing Li,

    Corresponding author
    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P. R. China
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  • Lei Jiang

    1. Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. China
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Abstract

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A photoinitiated thiol-yne click reaction strategy is used to fabricate a novel responsive biomimetic nanochannel platform. It displays a selective response for Cys by way of covalent bond formation on the channel surface. This system can be applied for Cys sensing with high specificity and non-interference performance in complex matrices and human urine samples.

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