Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy

Authors

  • Xian-Zhu Yang,

    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P.R. China
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    • [+]These authors contributed equally to this work.

  • Xiao-Jiao Du,

    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P.R. China
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    • [+]These authors contributed equally to this work.

  • Yang Liu,

    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P.R. China
    2. High Magnetic Field Laboratory of CAS, University of Science and Technology of China, Hefei, Anhui, China
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  • Yan-Hua Zhu,

    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P.R. China
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  • Yang-Zhong Liu,

    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P.R. China
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  • Ya-Ping Li,

    1. Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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  • Jun Wang

    Corresponding author
    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P.R. China
    2. High Magnetic Field Laboratory of CAS, University of Science and Technology of China, Hefei, Anhui, China
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Abstract

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Rationally designed PIC nanoparticles as next-generation delivery system: we have developed a core–shell–corona PIC nanoparticle NP/Pt@PPC-DA as a next-generation delivery system. NP/Pt@PPC-DA exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin-resistant tumor growth in a murine xenograft model has been successfully suppressed.

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