Get access

DNA-mediated Construction of Hollow Upconversion Nanoparticles for Protein Harvesting and Near-Infrared Light Triggered Release

Authors

  • Li Zhou,

    1. State Key Laboratory of Rare Earth Resource, Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin, China
    Search for more papers by this author
  • Zhaowei Chen,

    1. State Key Laboratory of Rare Earth Resource, Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin, China
    Search for more papers by this author
  • Kai Dong,

    1. State Key Laboratory of Rare Earth Resource, Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin, China
    Search for more papers by this author
  • Meili Yin,

    1. State Key Laboratory of Rare Earth Resource, Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin, China
    Search for more papers by this author
  • Jinsong Ren,

    1. State Key Laboratory of Rare Earth Resource, Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin, China
    Search for more papers by this author
  • Xiaogang Qu

    Corresponding author
    1. State Key Laboratory of Rare Earth Resource, Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin, China
    Search for more papers by this author

Abstract

image

A simple DNA-mediated solvothermal method has been developed for the construction of well-defined hollow UNPs that can be used for a new paradigm to realize NIR light-controlled non-invasive protein release. In vitro studies show that the UNPs are capable of the transportation of enzyme into living cells. Intracellular NIR triggers the release of enzymes with high spatial and temporal precision and the released enzyme also retains its biological activity.

Get access to the full text of this article

Ancillary