Get access
Advertisement

Directed Axonal Outgrowth Using a Propagating Gradient of IGF-1

Authors


Abstract

image

The temporospatial regulation of axon outgrowth is useful for guiding de novo connectivity or re-connectivity of neurons in neurological injury or disease. Here we report the successful construction of a biocompatible guidance device, in which a linear propagation of IGF-1 gradient sequentially directs axon outgrowth. We observe the extensive in vitro axonal extension over 5 mm with a desired growth rate of ∼1 mm/day.

Get access to the full text of this article

Ancillary