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Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine

Authors

  • Min Zheng,

    1. State Key Laboratory of Luminescence and Applications, Changchun Institute of OpticsFine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
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  • Shi Liu,

    1. State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
    2. University of Chinese Academy of Sciences, Beijing, P. R. China
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  • Jing Li,

    1. State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
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  • Dan Qu,

    1. State Key Laboratory of Luminescence and Applications, Changchun Institute of OpticsFine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
    2. University of Chinese Academy of Sciences, Beijing, P. R. China
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  • Haifeng Zhao,

    1. State Key Laboratory of Luminescence and Applications, Changchun Institute of OpticsFine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
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  • Xingang Guan,

    1. State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
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  • Xiuli Hu,

    1. State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
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  • Zhigang Xie,

    Corresponding author
    1. State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
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  • Xiabin Jing,

    1. State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
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  • Zaicheng Sun

    Corresponding author
    1. State Key Laboratory of Luminescence and Applications, Changchun Institute of OpticsFine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
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Abstract

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A theranostic nanomedicine (CD-Oxa) is synthesized by means of the condensation reaction between the amino groups on the surface of fluorescent carbon dots (CDs) and the carboxyl group of the oxaliplatin derivative Oxa(IV)-COOH. CD-Oxa, which integrates the optical properties of CDs and the anticancer function of oxaliplatin, could be used for simultaneous drug delivery and fluorescent tracking.

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