Cell Capture: Capture and Stimulated Release of Circulating Tumor Cells on Polymer-Grafted Silicon Nanostructures (Adv. Mater. 11/2013)

Authors

  • Shuang Hou,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Haichao Zhao,

    1. Yu Initiative Research Unit, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Libo Zhao,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
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  • Qinglin Shen,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
    2. Department of Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China
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  • Kevin S. Wei,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
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  • Daniel Y. Suh,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
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  • Aiko Nakao,

    1. RNC Industrial Cooperation Team, RIKEN, Wako, Saitama 351-0198, Japan
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  • Mitch A. Garcia,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
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  • Min Song,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
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  • Tom Lee,

    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
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  • Bin Xiong,

    1. Department of Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China
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  • Shyh-Chyang Luo,

    Corresponding author
    1. Yu Initiative Research Unit, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
    • Yu Initiative Research Unit, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
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  • Hsian-Rong Tseng,

    Corresponding author
    1. Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
    • Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770, USA
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  • Hsiao-hua Yu

    Corresponding author
    1. Yu Initiative Research Unit, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
    • Yu Initiative Research Unit, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
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Abstract

original image

Combining silicon nanostructures and thermoresponsive polymer brushes, a new nanoscale Velcrolike device is created by Hsiao-hua Yu, Hsian-Rong Tseng, Shyh-Chyang Luo, and co-workers on page 1547. At body temperature, these polymer brushes stick to the tumor cells and capture them with enhanced efficiencies (lower part of the image). When cooled, they release these cells with great viability (upper part of the image), allowing scientists to examine these cells.

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