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Keywords:

  • non-viral gene delivery;
  • supramolecular self-assembly;
  • mannose targeting;
  • cell penetrating peptides
Thumbnail image of graphical abstract

Supramolecular self-assembled nanocomplexes allow mannose receptormediated endocytosis and mediate membrane transduction via the pore formation mechanism, which facilitates effective cellular internalization and endosomal escape towards highly effective gene transfection, as reported by Jianjun Cheng and co-workers on page 3063.