Advertisement

Non-Viral Gene Delivery via Membrane-Penetrating, Mannose-Targeting Supramolecular Self-Assembled Nanocomplexes (Adv. Mater. 22/2013)

Authors

  • Lichen Yin,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, IL 61801, USA
    Search for more papers by this author
  • Ziyuan Song,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, IL 61801, USA
    Search for more papers by this author
  • Kyung Hoon Kim,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, IL 61801, USA
    Search for more papers by this author
  • Nan Zheng,

    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, IL 61801, USA
    Search for more papers by this author
  • Nathan P. Gabrielson,

    1. Institute of Genomic Biology, University of Illinois at Urbana-Champaign, 1206 W Gregory Drive, Urbana, IL 61801, USA
    Search for more papers by this author
  • Jianjun Cheng

    Corresponding author
    1. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, IL 61801, USA
    • Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, IL 61801, USA.
    Search for more papers by this author

Abstract

original image

Supramolecular self-assembled nanocomplexes allow mannose receptormediated endocytosis and mediate membrane transduction via the pore formation mechanism, which facilitates effective cellular internalization and endosomal escape towards highly effective gene transfection, as reported by Jianjun Cheng and co-workers on page 3063.

Ancillary