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Keywords:

  • carbon nanotubes;
  • field-effect transistors;
  • biosensors;
  • single molecule
Thumbnail image of graphical abstract

The Review by Xuefeng Guo on page 3397 highlights recent progress in the burgeoning field of single-molecule electrical biosensors based on single-walled carbon nanotubes, focusing on the molecular structures, interacting dynamics and molecular functions. Perspectives and key issues critical to the success of next-generation singlemolecule biosensors are discussed in terms of practical applications, such as the device reproducibility, system integration and theoretical simulation.