Microencapsulation: Microencapsulation of Chemotherapeutics into Monodisperse and Tunable Biodegradable Polymers via Electrified Liquid Jets: Control of Size, Shape, and Drug Release (Adv. Mater. 33/2013)

Authors

  • Pouria Fattahi,

    1. Departments of Bioengineering and Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
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  • Ali Borhan,

    1. Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
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  • Mohammad Reza Abidian

    Corresponding author
    1. Departments of Bioengineering, Materials Science & Engineering and Chemical Engineering, Materials Research Institute, Pennsylvania State University, University Park, PA 16802, USA
    • Departments of Bioengineering, Materials Science & Engineering and Chemical Engineering, Materials Research Institute, Pennsylvania State University, University Park, PA 16802, USA.===

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Abstract

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On page 4555, Mohammad Reza Abidian and co-workers describe the use of an electrojetting technique, whereby a conducting liquid is injected at a constant flow rate through a high-voltage electrified capillary tube, for the microencapsulation of the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea into biodegradable polymer poly(lactic-co-glycolic acid). The technique results in microcapsules having high drug encapsulation efficiency, tunable drug loading capacity, and narrow size distribution.

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