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Drug Delivery: Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery (Adv. Mater. 33/2013)

Authors

  • Yunlong Zhang,

    1. David H. Koch Institute for Integrative, Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
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  • Jeisa M. Pelet,

    1. David H. Koch Institute for Integrative, Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
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  • Daniel A. Heller,

    1. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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  • Yizhou Dong,

    1. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
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  • Delai Chen,

    1. David H. Koch Institute for Integrative, Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Zhen Gu,

    1. David H. Koch Institute for Integrative, Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
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  • Brian J. Joseph,

    1. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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  • Jasmine Wallas,

    1. Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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  • Daniel G. Anderson

    Corresponding author
    1. David H. Koch Institute for Integrative, Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
    4. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Boston, MA 02139, USA
    • David H. Koch Institute for Integrative, Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.===

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Abstract

original image

The self-assembled nanoparticles for siRNA delivery with lipid-modified aminoglycoside derivatives is described by Daniel G. Anderson and co-workers on page 4641. The core-shell nanoparticles can protect siRNA from enzymatic degradation within the body and subsequently deliver siRNA into cytoplasm of target cells. The image is courtesy of Dr. Ning Zhang.

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