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Keywords:

  • self-folding;
  • expansion ratio;
  • angiogenesis;
  • neovascularization;
  • drug delivery
Thumbnail image of graphical abstract

Multiwalled poly(ethylene glycol) diacrylate (PEGDA) hydrogel tubes are assembled via in situ self-folding of a bilayered hydrogel patch with different expansion ratios and rigidity between the two layers, as described by Hyunjoon Kong and co-workers on page 5568. The resulting gel tubes exhibit unidirectional, sustained release of proangiogenic growth factors and significantly stimulated vascularization around the gel implant.