Get access
Advanced Materials

A Bubble-Mediated Intelligent Microscale Electrochemical Device for Single-Step Quantitative Bioassays

Authors

  • Fan Yang,

    1. Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    2. School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China
    Search for more papers by this author
    • These authors contributed equally to this work

  • Xiaolei Zuo,

    1. Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    Search for more papers by this author
    • These authors contributed equally to this work

  • Zhenhua Li,

    1. Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    Search for more papers by this author
  • Wangping Deng,

    1. Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    Search for more papers by this author
  • Jiye Shi,

    1. Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    2. UCB Pharma, Slough, UK
    Search for more papers by this author
  • Guojun Zhang,

    1. School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China
    Search for more papers by this author
  • Qing Huang,

    1. Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    Search for more papers by this author
  • Shiping Song,

    1. Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    Search for more papers by this author
  • Chunhai Fan

    Corresponding author
    1. Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    Search for more papers by this author

Abstract

An intelligent microscale electrochemical device (iMED) for one-step, quantitative and multiplexed electrochemical detection of biomarkers for infectious diseases and tumors is developed. A “plug-in-cartridge” technology is introduced and adapted for use in screen-printed electrodes (SPEs) in electrochemical devices. Using this iMED, biomarkers for two types of tumors and one infectious disease are detected at sub-ng/mL levels in less than 30 min.

image
Get access to the full text of this article

Ancillary