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Biodegradable Nanofibrous Polymeric Substrates for Generating Elastic and Flexible Electronics

Authors

  • Alireza Hassani Najafabadi,

    1. Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
    3. Department of Chemistry, Amirkabir University of Technology, Tehran, Iran
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    • A. Hassani Najafabadi and A. Tamayol contributed equally to this work.

  • Ali Tamayol,

    1. Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
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    • A. Hassani Najafabadi and A. Tamayol contributed equally to this work.

  • Nasim Annabi,

    1. Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
    3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA
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  • Manuel Ochoa,

    1. School of Electrical and Computer Engineering, Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA
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  • Pooria Mostafalu,

    1. Department of Electrical and Computer Engineering, Tufts University, Medford, MA, USA
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  • Mohsen Akbari,

    1. Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
    3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA
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  • Mehdi Nikkhah,

    1. Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
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    • Present address: School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA

  • Rahim Rahimi,

    1. School of Electrical and Computer Engineering, Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA
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  • Mehmet R. Dokmeci,

    1. Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
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  • Sameer Sonkusale,

    1. Department of Electrical and Computer Engineering, Tufts University, Medford, MA, USA
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  • Babak Ziaie,

    1. School of Electrical and Computer Engineering, Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA
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  • Ali Khademhosseini

    Corresponding author
    1. Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
    3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA
    4. Department of Physics, King Abdulaziz University, Jeddah, Saudi Arabia
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Abstract

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Biodegradable nanofibrous polymeric substrates are used to fabricate suturable, elastic, and flexible electronics and sensors. The fibrous microstructure of the substrate makes it permeable to gas and liquid and facilitates the patterning process. As a proof-of-principle, temperature and strain sensors are fabricated on this elastic substrate and tested in vitro. The proposed system can be implemented in the field of bioresorbable electronics and the emerging area of smart wound dressings.

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