Photothermal Therapy: Multifunctional Fe5C2 Nanoparticles: A Targeted Theranostic Platform for Magnetic Resonance Imaging and Photoacoustic Tomography-Guided Photothermal Therapy (Adv. Mater. 24/2014)

Authors

  • Jing Yu,

    1. Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China
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  • Ce Yang,

    1. Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China
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  • Jingdingsha Li,

    1. Institute of Medical Physics, Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, China
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  • Yichen Ding,

    1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China
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  • Lei Zhang,

    1. Department of Radiology, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, China
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  • Muhammad Zubair Yousaf,

    1. Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China
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  • Jian Lin,

    1. Synthetic and Functional Biomolecules Center, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
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  • Rui Pang,

    1. Institute of Medical Physics, Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, China
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  • Lanbin Wei,

    1. Institute of Medical Physics, Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, China
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  • Lili Xu,

    1. Department of Radiology, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, China
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  • Fugeng Sheng,

    Corresponding author
    1. Department of Radiology, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, China
    • Fugeng Sheng, Department of Biomedical Engineering===, College of Engineering===, Peking University===, Beijing=== 100871=== China=== ===

      Lingyun Zhao, Institute of Medical Physics===, Key Laboratory of Particle & Radiation Imaging===, Ministry of Education===, Department of Engineering Physics===, Tsinghua University===, Beijing=== 100084=== China=== ===

      Yanglong Hou, Department of Materials Science and Engineering===, College of Engineering===, Peking University===, Beijing=== 100871=== China=== ===

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  • Changhui Li,

    1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China
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  • Gongjie Li,

    1. Department of Radiology, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, China
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  • Lingyun Zhao,

    Corresponding author
    1. Institute of Medical Physics, Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing, China
    • Fugeng Sheng, Department of Biomedical Engineering===, College of Engineering===, Peking University===, Beijing=== 100871=== China=== ===

      Lingyun Zhao, Institute of Medical Physics===, Key Laboratory of Particle & Radiation Imaging===, Ministry of Education===, Department of Engineering Physics===, Tsinghua University===, Beijing=== 100084=== China=== ===

      Yanglong Hou, Department of Materials Science and Engineering===, College of Engineering===, Peking University===, Beijing=== 100871=== China=== ===

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  • Yanglong Hou

    Corresponding author
    1. Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China
    • Fugeng Sheng, Department of Biomedical Engineering===, College of Engineering===, Peking University===, Beijing=== 100871=== China=== ===

      Lingyun Zhao, Institute of Medical Physics===, Key Laboratory of Particle & Radiation Imaging===, Ministry of Education===, Department of Engineering Physics===, Tsinghua University===, Beijing=== 100084=== China=== ===

      Yanglong Hou, Department of Materials Science and Engineering===, College of Engineering===, Peking University===, Beijing=== 100871=== China=== ===

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Abstract

image

A novel multifunctional nano-probe is developed on page 4114 by Y. Hou, L. Zhao, F. Sheng, and co-workers based on Fe5C2 nanoparticles with carbon layer. The probe exhibits high magnetization and near infrared absorption, which can be applied in magnetic resonance imaging, photoacoustic tomography, and photothermal therapy. It shows a high affinity to tumors, and can ablate them when exposed to light, highlighting their potential as a targeted probe for cancer theranostics.

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