Porous Polymer and Cell Composites That Self-Assemble In Situ (pages 210–213)
A.K. Salem, F.R.A.J. Rose, R.O.C. Oreffo, X. Yang, M.C. Davies, J.R. Mitchell, C.J. Roberts, S. Stolnik-Trenkic, S.J.B. Tendler, P.M. Williams and K.M. Shakesheff
Article first published online: 13 FEB 2003 | DOI: 10.1002/adma.200390047
A cell-laden 3D network is formed upon the addition of avidin to biotinylated polymer particles in the presence of a suspension of cells (see Figure). Applications in tissue engineering and drug delivery are demonstrated; a shape-retaining biomaterial is formed within minutes of injecting the components into a cavity. The molecular interaction mechanism of self-assembly differentiates this polymer/cell composite from other injectable systems.