Silica Particles: A Novel Drug-Delivery System (pages 1959–1966)
C. Barbé, J. Bartlett, L. Kong, K. Finnie, H. Q. Lin, M. Larkin, S. Calleja, A. Bush and G. Calleja
Article first published online: 30 NOV 2004 | DOI: 10.1002/adma.200400771
Silica particles present an interesting alternative to organic systems for drug delivery. Combining sol–gel synthesis with emulsion technology can produce particles (see Figure) with independently controlled size and release rates. The particle size is controlled by the emulsion chemistry, while the release rate is controlled by the particle microstructure. Preliminary in-vivo experiments reveal enhanced blood stability of the nanoparticles, which, coupled with sustained release of anti-tumor agents, show good potential for cancer treatment.