Self-Rupturing Microcapsules (pages 2357–2361)
B. G. De Geest, C. Déjugnat, G. B. Sukhorukov, K. Braeckmans, S. C. De Smedt and J. Demeester
Article first published online: 16 AUG 2005 | DOI: 10.1002/adma.200401951
Self-rupturing microcapsules are prepared by layer-by-layer coating of degradable dextran-hydroxyethyl methacrylate microgels with the polyelectrolytes poly(allylamine hydrochloride) and sodium poly(styrene sulfonate). When the microgel core degrades, the swelling pressure increases and, at a critical value of the swelling pressure, the surrounding membrane suddenly ruptures (see Figure). This type of microcapsule could be very promising for pulsed drug delivery.