Fluorescent Polystyrene–Fe3O4 Composite Nanospheres for In Vivo Imaging and Hyperthermia (pages 2170–2173)
Donglu Shi, Hoon Sung Cho, Yan Chen, Hong Xu, Hongchen Gu, Jie Lian, Wei Wang, Guokui Liu, Christopher Huth, Lumin Wang, Rodney C. Ewing, Sergei Budko, Giovanni M. Pauletti and Zhongyun Dong
Version of Record online: 13 MAR 2009 | DOI: 10.1002/adma.200803159
Quantum dots (QDs) are immobilized on the surfaces of magnetic Fe3O4-composite nanospheres (MNSs, see figure). The QDs exhibit intense visible-light emission in fluorescence spectroscopy and successfully facilitate, for the first time, in vivo soft-tissue imaging in live mice. The Fe3O4 nanoparticles respond to an external magnetic field by increasing the temperature of the surrounding environment (i.e., hyperthermia), which can be used therapeutically.